Molecular Biology
Home
The nitty, gritty details.
Diagram of Replication Pathways
Transcription
The Big Picture of Alphavirus Replication
Genome:
+ssRNA, naked genome is infectious
linear, monopartite
5' structural proteins
Replication in cytoplasm
Morphology
Enveloped icosahedron
T=3
1 capsid protein
Transcription
2 mRNAs: genomic and subgenomic
Genomic: ORF-1 codes nonstructural genes
Subgenomic: ORF-2 codes structural genes
mRNAs are capped and poly-adenylated
Translation
Polyprotein
protein products are cleaved from large polyprotein
